Pang, Jiafeng, Li, Zhixian, Li, Shaomin, Lin, Shuying, Wang, Hongdi  ORCID: https://orcid.org/0000-0001-9690-962X, Xie, Qiuling and Jiang, Yanbin
2018.
Folate-conjugated zein/Fe3O4 nanocomplexes for the enhancement of cellular uptake and cytotoxicity of gefitinib.
Journal of Materials Science
53
(21)
, pp. 14907-14921.
10.1007/s10853-018-2684-7
|
Abstract
Integrating various functional components into a single nano-platform is an ideal but challenging strategy for cancer therapy. Herein, a facile approach to fabricating multi-targeted nano-drug delivery systems which can be monitored is reported. Superparamagnetic iron oxide nanoparticles (SPIONs) and gefitinib (GEF) were encapsulated into folic acid-conjugated zein (Fa–zein) nanocomplexes (GEF-FSZs) with good dispersity, high GEF loading efficiency and pH-dependent release profile. The uptake of water-insoluble GEF was facilitated by encapsulating GEF into a zein-based nanocomplex, the magnetic responsive property endowed by SPIONs and the conjugation of Fa, which resulted in enhanced toxicity to A549 cells. The endocytosis study indicated that macropinocytosis and clathrin/caveolae-independent endocytosis exerted great influence on the internalization of GEF-FSZs. These results implied that GEF-FSZs could be a promising candidate for controlled and targeted drug delivery.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Engineering |
| Publisher: | Springer |
| ISSN: | 0022-2461 |
| Date of Acceptance: | 10 July 2018 |
| Last Modified: | 29 Apr 2026 23:09 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/176451 |
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