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Tissue-specific stem cell differentiation in an in vitro airway model

Prytherch, Zoë Cariad ORCID:, Job, Claire Alison, Marshall, Hillary, Foster, Martyn and Berube, Kelly Ann ORCID: 2011. Tissue-specific stem cell differentiation in an in vitro airway model. Macromolecular Bioscience 11 (11) , pp. 1467-1477. 10.1002/mabi.201100181

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The respiratory tract is the primary site of exposure to airborne compounds, with the bronchial epithelium providing one of the first lines of defence. A growing need exists for an accurate in vitro model of the bronchial epithelium. Here, normal human bronchial epithelial (NHBE) cells cultured at an air/liquid interface create a fully differentiated, in-vivo-like model of the human bronchial epithelium. Developmental characterisation includes (i) trans-epithelial electrical resistance, (ii) morphology and (iii) bronchial cell specific stains/markers. It is concluded that the basal/progenitor cells create a pseudo-stratified, mucociliary NHBE model containing basal, serous, Clara, goblet and ciliated cells, reflective of the normal human bronchial epithelium (days 24–33 ALI culture).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: bioengineering; biomimetics; human airway epithelium; in vitro models; tissue engineering
Additional Information: Article first published online: 12 OCT 2011
Publisher: Wiley-Blackwell
ISSN: 1616-5187
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Last Modified: 19 Oct 2022 08:33

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