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Why cannot a rodent be more like a man? A clinical perspective

Rosser, Anne Elizabeth ORCID: 2012. Why cannot a rodent be more like a man? A clinical perspective. Lane, Emma Louise and Dunnett, Stephen Bruce, eds. Animal models of movement disorders, Vol. 1. Neuromethods, vol. 61. New York: Humana Press, pp. 3-9. (10.1007/978-1-61779-298-4_1)

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Neurodegeneration is largely limited to humans, with spontaneous neurodegenerative conditions being extremely rare in animals. However, whole animal models are crucial for a proper understanding of the neurodegenerative process as well as essential for preclinical assessment of novel therapies. Thus, it has been necessary to generate animal models of neurodegeneration using a combination of techniques, including injectable toxins and genetic manipulation. Given the constraints inherent in these approaches, how successful are animal models of neurodegeneration and how can such models be refined in the future?

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > Q Science (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Experimental medicine ; Translation ; Clinical studies ; Animal studies ; Validity
Publisher: Humana Press
ISBN: 9781617792977
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Last Modified: 19 Oct 2022 08:35

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