Research priorities for polycystic ovary syndrome

Channon, Susan ORCID: https://orcid.org/0000-0002-5394-1483, Coulman, Elinor, Morman, Rachel, Andrews, Caroline, Morgan, Fiona, Watson, Jo, Hounsome, Juliet ORCID: https://orcid.org/0000-0002-2026-3778, Teede, Helena and Rees, Aled ORCID: https://orcid.org/0000-0002-1165-9092 2026. Research priorities for polycystic ovary syndrome. The Lancet Obstetrics, Gynaecology, & Women’s Health 2 (4) , pp. e272-e274. 10.1016/s3050-5038(26)00018-x

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Abstract

Polycystic ovary syndrome is a common, chronic endocrine disorder associated with adverse reproductive, cardiometabolic, and psychosocial outcomes that impair quality of life. The 2023 International Polycystic Ovary Syndrome guideline represents an important advance in clinical care, but many of its recommendations rely on low-quality evidence. This reflects a longstanding underinvestment in polycystic ovary syndrome research relative to its substantial disease burden, an imbalance driven by a failure to appreciate the breadth of its manifestations and the profound effect on the lives of patients. Co-production of research priorities is essential to ensure relevance and avoid a disconnect between funded research and patient needs. In 2023, the International Polycystic Ovary Syndrome Network developed a co-produced clinical research priority roadmap with more than 150 research recommendations, but did not include a formal ranking exercise to identify the most important research questions.2 The James Lind Alliance (JLA) facilitates priority setting partnerships, bringing together people with lived experience, carers, and health-care professionals to collaboratively identify and prioritise key areas for research, using robust, inclusive, and transparent methodology, which places an emphasis on joint decision making. We established the JLA priority setting partnerships in polycystic ovary syndrome in the UK as a collaboration between Cardiff University and Verity, a UK polycystic ovary syndrome charity, with the aim of jointly identifying the most important areas for research for this common condition.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > Centre for Trials Research (CNTRR)
Additional Information:	RRS applied.
Publisher:	Elsevier
ISSN:	3050-5038
Date of First Compliant Deposit:	16 January 2026
Date of Acceptance:	16 January 2026
Last Modified:	20 May 2026 11:15
URI:	https://orca.cardiff.ac.uk/id/eprint/183967

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