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Defining the pupillary component of the perioculomotor preganglionic population within a unitary primate Edinger-Westphal nucleus

May, Paul J., Sun, Wensi and Erichsen, Jonathan Thor 2008. Defining the pupillary component of the perioculomotor preganglionic population within a unitary primate Edinger-Westphal nucleus. In: Kennard, C. and Leigh, R. J. eds. Using Eye Movements as an Experimental Probe of Brain function - A Symposium in Honor of Jean Büttner-Ennever, Progress in Brain Research, vol. 171. Amsterdam: Elsevier, pp. 97-106. (10.1016/S0079-6123(08)00613-4)

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The primate Edinger–Westphal nucleus (EW) contains perioculomotor preganglionic (pIIIPG) motoneurons that control the lens and pupil. Separate subdivisions have been described in EW and termed visceral columns, with the lateral visceral column (lvc) reportedly receiving pretectal inputs for the pupillary light reflex. However, choline acetyl transferase staining reveals a single paired column of cells dorsal to the oculomotor nucleus, suggesting the EW is not subdivided. We investigated this issue by transneuronal retrograde labelling of pIIIPG neurons in three monkey species. In all three, pIIIPG neurons were contained in a single column. We have also examined which part of the macaque pIIIPG population receives pretectal input. Injections of biocytin into the pretectum anterogradely labelled terminals that lay in close association with pIIIPG motoneurons retrogradely labelled by ciliary ganglion injections of WGA-HRP. These close associations were concentrated in the ventromedial portion of the middle third of EW, suggesting this pIIIPG region mediates pupillary control. In other cases, pretectal WGA-HRP injections, in addition to labelling terminals in the EW, produced a circular field of labelled neurons, and terminals in the periaqueductal grey, dorsolateral to EW. This region may represent the previously designated lvc, but it does not contain pIIIPG motoneurons.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Uncontrolled Keywords: oculomotor; near response; pupil; para sympathetic
Publisher: Elsevier
ISBN: 9780444531636
ISSN: 00796123
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Last Modified: 04 Jun 2017 03:14

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