The peptide ligands presented by MHC class II molecules

Cole, David ORCID: https://orcid.org/0000-0003-0028-9396 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2016. The peptide ligands presented by MHC class II molecules. Encyclopedia of Immunobiology, Elsevier, pp. 209-214. (10.1016/B978-0-12-374279-7.06010-0)

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Abstract

The realization in the late 1980s that TCRs recognized short peptide fragments presented by MHC molecules opened up a whole new area of experimental immunology exploring the exact nature of such peptides, how they are generated, and the manner in which the TCR interacts with them. The range of peptides presented by a particular MHC molecule on a cell type has recently been given the term ligandome. The importance of the ligandome for each MHC type can be broadly divided into two key areas: first, elucidating the ligandome helps define an MHC-specific binding motif that then enables predictions to be made about what type of peptide fragments may be presented from a unique previously unexplored protein antigen; second, the technical ability to now elute large numbers of peptides from tissue-derived purified MHC molecules means unique peptide epitopes may be identified and employed in downstream platforms for vaccine design. MHC class II molecules present peptides to cognate CD4+ T cells, these cells being crucial for facilitating B cell and CD8+ T cell responses, and hence understanding the nature of the ligands presented is an important first step for designing effective immune-based treatments.

Item Type:	Book Section
Status:	Published
Schools:	Schools > Medicine
Publisher:	Elsevier
ISBN:	9780080921525
Last Modified:	24 Mar 2026 13:45
URI:	https://orca.cardiff.ac.uk/id/eprint/185987

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