Baddeley, Elin, Font, Carme, Mahé, Isabelle, Edwards, Michelle  ORCID: https://orcid.org/0000-0001-7432-2828, Sivell, Stephanie ORCID: https://orcid.org/0000-0003-0253-1860, Lifford, Kate J. ORCID: https://orcid.org/0000-0002-9782-2080, Arfuch, Victoria Mailen, Coma-Auli, Nuri, Søgaard, Mette, Enggaard, Helle, Helfer, Hélène, Mohammed, Nassima Si, Seddon, Kathy, Mooijaart, Simon P., Pearson, Mark, Szmit, Sebastian, Klok, F.A., Noble, Simon ORCID: https://orcid.org/0000-0001-5425-2383, Højen, Anette Arbjerg and SERENITY consortium
2026.
Clinician perspectives on antithrombotic therapy management in advanced cancer: a multi-national qualitative study.
Research and Practice in Thrombosis and Haemostasis
10
(3)
, 103427.
10.1016/j.rpth.2026.103427
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Abstract
Introduction: Decision-making about antithrombotic therapy (ATT) in patients with advanced cancer near the end of life is fraught with clinical uncertainty and can significantly affect care. Despite its importance and complexity, ATT is often deprioritised or guided by legacy prescribing and monitoring patterns. Management spans multiple specialties, with roles and responsibilities frequently blurred. Clinicians’ perspectives remain largely underexplored, which are crucial to inform improved care models. Aim: To explore clinicians’ experiences of current practice of continuing and deprescribing ATT in patients with advanced cancer at the end of life. Methods: Qualitative methodology using semi-structured interviews with clinicians involved in ATT management at the end of life, across Denmark, France, Spain and the United Kingdom. Data were analysed using Framework Analysis. Results: Eighty clinicians across a range of specialties were interviewed. Two major themes were generated. 1) Balancing complexities in ATT management: clinicians reported several challenges, from ambiguity surrounding roles and responsibilities, delicacy around timing, and variance in risk perceptions of ATT, balanced with patient preferences; 2) Culture of continuation: clinicians described a general and ATT-specific culture of continuation, and reported a passivity in relation to ATT review. Conclusions: The management of ATT in this context is multifaceted, influenced by many competing factors. These complexities need to be understood and addressed to support decision-making related to ATT at the end of life.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > Marie Curie Palliative Care Research Centre (MCPCRC) |
| Publisher: | Elsevier |
| ISSN: | 2475-0379 |
| Funders: | Innovate UK |
| Projects: | 10039823 |
| Date of First Compliant Deposit: | 31 March 2026 |
| Date of Acceptance: | 16 February 2026 |
| Last Modified: | 02 Jun 2026 14:54 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/186120 |
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