Genetic score associations with birthweight in preterm-born infants compared with term-born infants

Beaumont, Robin N., Kotecha, Sarah J., Simpson, Shannon J., Kotecha, Sailesh ORCID: https://orcid.org/0000-0003-3535-7627 and Freathy, Rachel M. 2026. Genetic score associations with birthweight in preterm-born infants compared with term-born infants. Scientific Reports 16 , 15082. 10.1038/s41598-026-45823-4

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Abstract

In preterm infants, lower birthweight correlates with a higher risk of neonatal complications. Understanding the factors influencing birthweight in these infants is important as it may guide future antenatal and perinatal care. Genetic variants account for at least one-quarter of variation in birthweight in term-born infants, but the genetic contribution to birthweight in preterm infants is not well understood. We aimed to compare genetic score associations with birthweight in a sample of preterm infants with those in term-born infants. Linear regression was used to test the association between birth weight and fetal genetic scores for birthweight (BW-GS) in a total of 1,416 preterm, and 15,253 term, singleton infants. Analyses, adjusted for ancestry principal components were performed within each of 4 datasets and meta-analysed. In term-born infants: a 1 SD higher BW-GS was associated with a 1.20 (95% CI 1.10–1.29) SD higher birthweight. In preterm infants, there was also strong evidence of association, but with a smaller effect size (0.76SD (0.41–1.11) higher birthweight per 1-SD higher BW-GS). In preterms, when stratifying by gestational duration, we found that the associations strengthened with increasing gestational duration. Genetic scores composed of variants identified in term-born infants also influenced birthweight in preterm infants. However, the associations had smaller effects in preterms and were weaker at earlier gestations. This suggests that while many of the same genetic factors influence birthweight in preterm and term-born infants, other factors (environmental, placental, different genetic) may be more important in preterms. Future well-powered studies are required to investigate this.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	Nature Publishing Group
ISSN:	2045-2322
Date of First Compliant Deposit:	7 April 2026
Date of Acceptance:	23 March 2026
Last Modified:	03 Jun 2026 09:47
URI:	https://orca.cardiff.ac.uk/id/eprint/186213

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