Nonuniform association of genetic risk scores for intraocular pressure

He, Xi, Huang, Yu, Plotnikov, Denis, Terry, Louise ORCID: https://orcid.org/0000-0002-6200-8230 and Guggenheim, Jeremy ORCID: https://orcid.org/0000-0001-5164-340X 2026. Nonuniform association of genetic risk scores for intraocular pressure. JAMA Ophthalmology 144 (6) , pp. 508-516. 10.1001/jamaophthalmol.2026.1022

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Abstract

Importance Elevated intraocular pressure (IOP) is a risk factor for primary open-angle glaucoma, and genetic risk scores hold promise as a tool for screening for ocular hypertension. However, genetic risk scores for IOP have a nonuniform association across the range of IOP, which reduces their accuracy. Objective To test the hypothesis that nonuniform behavior of genetic risk scores for IOP is associated with a specific type of genetic interaction. Design, Setting, and Participants Cross-sectional, post hoc genetic association studies were performed using linear and quantile regression in a sample of UK Biobank participants. Data were analyzed from January to September 2025. Exposures Ninety-eight genetic variants associated with IOP...

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Optometry and Vision Sciences
Additional Information:	RRS applied
Publisher:	American Medical Association
ISSN:	2168-6173
Date of First Compliant Deposit:	13 April 2026
Date of Acceptance:	4 March 2026
Last Modified:	01 Jul 2026 14:45
URI:	https://orca.cardiff.ac.uk/id/eprint/186351

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