Advanced neuroimaging in PCOS: state-of-the-art techniques and emerging trends

Wright, Melissa E. ORCID: https://orcid.org/0000-0002-2744-4504, Rees, D. Aled ORCID: https://orcid.org/0000-0002-1165-9092 and Murphy, Kevin ORCID: https://orcid.org/0000-0002-6516-313X 2026. Advanced neuroimaging in PCOS: state-of-the-art techniques and emerging trends. Journal of Endocrinology 269 (2) 10.1530/JOE-25-0421

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Abstract

Modern neuroimaging advances in methodology and data modelling allow for brain tissue structure and function to be imaged in increasing detail and specificity. These advances have promise when applied to Polycystic Ovary Syndrome (PCOS), a common multi-system condition associated with psycho-cognitive symptomatology and increased risk of cerebrovascular disease. This hot-topic review will outline three biological themes that encompass PCOS neurobiology and symptomatology, which may benefit from the application of advanced neuroimaging techniques: 1) the endocrine system and biorhythms, 2) the cerebrovascular system, and 3) neural structure and function. How modern neuroimaging advances can provide new insights to these areas will be discussed. While knowledge of brain health in PCOS is still an emerging field, advanced neuroimaging offers valuable opportunities to investigate the origins and enduring consequences of PCOS.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Schools > Physics and Astronomy Research Institutes & Centres > Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	BioScientifica
ISSN:	0022-0795
Date of First Compliant Deposit:	22 April 2026
Date of Acceptance:	21 April 2026
Last Modified:	03 Aug 2026 09:45
URI:	https://orca.cardiff.ac.uk/id/eprint/186579

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