Sex based differences in IPSC derived nociceptor responses to osteoarthritic synovial fluid [Abstract]

Jones, Ryan, Gilbert, Sophie, White, Paul and Mason, Deborah ORCID: https://orcid.org/0000-0002-8666-6094 2026. Sex based differences in IPSC derived nociceptor responses to osteoarthritic synovial fluid [Abstract]. Osteoarthritis and Cartilage 34 (S) , pp. S370-S371. 10.1016/j.joca.2026.01.534

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Abstract

Purpose (the aim of the study): Osteoarthritic pain affects 18% of females and 9.6% of males over 60 worldwide, with 62% of all osteoarthritic patients being female. Women use more health care, have higher osteoarthritis prevalence, suffer more from debilitating pain, particularly post-menopause, and have more rapid disease progression. However, the molecular drivers underlying the differences between males and females, and post-menopause, in osteoarthritic pain and pathology is unknown. We used a human iPSC derived nociceptor model to determine whether responses to human synovial fluids are sex specific, relate to systemic oestradiol concentrations and correlate with synovial fluid proteins.

Item Type:	Short Communication
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Publisher:	Elsevier
ISSN:	1063-4584
Last Modified:	05 May 2026 14:10
URI:	https://orca.cardiff.ac.uk/id/eprint/186771

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