273. Largest study of mitochondrial DNA variants increasing risk for schizophrenia [Abstract]

Gonçalves, Vanessa, Dos Santos, Fernanda, Pardinas, Antonio ORCID: https://orcid.org/0000-0001-6845-7590, Vawter, Marquis, Kennedy, James and PGC-SCZ working group 2026. 273. Largest study of mitochondrial DNA variants increasing risk for schizophrenia [Abstract]. Biological Psychiatry 99 (10) , p. S216. 10.1016/j.biopsych.2026.03.507

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Abstract

Schizophrenia (SCZ) is a complex disorder with both clinical and biological heterogeneity, and to date, effective diagnosis, treatment and prevention strategies are largely absent. Mitochondrial DNA (mtDNA) plays a crucial role in the brain suggesting that genetic variants in this system may contribute to the etiology of mental illnesses. However, due to lack of analytical workflow to guide researchers on unique features of mtDNA, large genomics consortia has been removing this genome from analysis.

Item Type:	Short Communication
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	Elsevier
ISSN:	0006-3223
Last Modified:	06 May 2026 15:15
URI:	https://orca.cardiff.ac.uk/id/eprint/186832

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