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Cell-based treatments for Huntington's disease

Dunnett, Stephen Bruce ORCID: and Rosser, Anne Elizabeth ORCID: 2011. Cell-based treatments for Huntington's disease. International Review of Neurobiology 98 , pp. 483-508. 10.1016/B978-0-12-381328-2.00017-1

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In experimental rats, mice, and monkeys, transplantation of embryonic striatal cells into the striatum can repair the damage and alleviate the functional deficits caused by striatal lesions. Such strategies have been translated to striatal repair by cell transplantation in small numbers of patients with progressive genetic striatal degeneration in Huntington's disease. In spite of some encouraging preliminary data, the clinical results are to date neither as reliable nor as compelling as the broad extend of recovery observed in the animal models across motor, cognitive, and skill and habit learning domains. Strategies to achieve immediate and long-term improvements in the clinical applications include identifying and limiting the causes of complications, standardization and quality control of preparation and delivery, appropriate patient selection to match the cellular repair to specific profiles of cell loss and degeneration in individual patients and different neurodegenerative diseases, and improving the availability of alternative sources of donor cells and tissues.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: neural transplantation; striatal grafts; Huntington's disease; cell therapy; fetal tissues; stem cells; motor disorders; cognitive disorders; plasticity
Publisher: Elsevier
ISSN: 0074-7742
Last Modified: 19 Oct 2022 08:42

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