Numbering-up flow electroreduction of α,β-unsaturated carbonyls from gram to pilot-relevant scale

Boruah, Tribani, Arepally, Sagar, Melen, Rebecca L. ORCID: https://orcid.org/0000-0003-3142-2831 and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2026. Numbering-up flow electroreduction of α,β-unsaturated carbonyls from gram to pilot-relevant scale. Organic Process Research & Development 30 (7) , pp. 2067-2074. 10.1021/acs.oprd.6c00175

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Abstract

A scalable flow electrochemical platform achieves up to 9.2 g/h productivity at a 100 g scale using an innovative three-electrode reactor design. Dual-sided cathodes enable 16 parallel channels across eight modules, maintaining 1 min residence time without reoptimization. The methodology processes diverse α,β-unsaturated carbonyl substrates (chalcones, heterocyclic enones, esters, ketones, carboxylic acids), explored 18 examples with broad functional group tolerance. The average productivity improvement across the substrates is 75-fold than the batch method with consistent performance from gram to pilot scale, establishing a cost-effective pathway for the electrochemical reduction reaction.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Publisher:	American Chemical Society
ISSN:	1083-6160
Funders:	EPSRC
Projects:	EP/T019719/1
Date of First Compliant Deposit:	7 July 2026
Date of Acceptance:	16 June 2026
Last Modified:	25 Sep 2026 09:41
URI:	https://orca.cardiff.ac.uk/id/eprint/188002

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