Advances in diffusion MRI in Huntington's disease

Metzler-Baddeley, Claudia ORCID: https://orcid.org/0000-0002-8646-1144, Puig-Davi, Arnau, Camara, Estela, De Diego-Balaguer, Ruth and Sampedro, Frederic 2026. Advances in diffusion MRI in Huntington's disease. Sampedro, Frederic, ed. Advances in Diffusion Magnetic Resonance Imaging for Neurodegenerative Diseases Research, Academic Press, pp. 77-102. (10.1016/B978-0-443-23812-3.00011-4)

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Abstract

n this chapter, the authors describe the advances in diffusion-weighted imaging in Huntington's disease research. Given the well-known genetic basis of this neurogenerative disorder, incipient brain damage in very early disease stages can be well characterized, and optimal prognostic biomarkers can be designed. Although diffusion imaging remains primarily a research tool in this disorder, classic and novel metrics using this modality have shown promising value for disease-monitoring in clinical trials and have provided a better understanding of its motor and especially nonmotor symptoms.

Item Type:	Book Section
Date Type:	Published Online
Status:	Published
Schools:	Schools > Psychology Research Institutes & Centres > Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Academic Press
ISBN:	9780443238123
Last Modified:	10 Jul 2026 10:45
URI:	https://orca.cardiff.ac.uk/id/eprint/188034

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