Two for the price of one: a dual treatment benefit of long-acting octreotide in occult bleeding and diuretic intractable ascites

Lee, Bee Leng, Turner, Jeff, Hurley, Joanna, Green, John, Hawkes, Neil and Alcolado, Ruth 2011. Two for the price of one: a dual treatment benefit of long-acting octreotide in occult bleeding and diuretic intractable ascites. Frontline Gastroenterology 2 (4) , pp. 226-229. 10.1136/fg.2010.003459

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Abstract

Transfusion-dependent anaemia and portal hypertension are recognised complications of hereditary haemorrhagic telangiectasia (HHT). The anaemia is a result of chronic bleeding from gastrointestinal telangiectasias, which are usually multiple and located throughout the gastrointestinal tract. As a result, treatment with argon plasma coagulation via gastroscopy and or colonoscopy is often insufficient to prevent ongoing blood loss. Portal hypertension in HHT occurs as a result of blood shunting between the hepatic artery and the portal vein within the liver. The somatostatin analogue octreotide has been used as a treatment for bleeding angiodysplasia; however, its possible role as a treatment for diuretic intractable ascites secondary to portal hypertension has not been previously established. The authors report a case that apparently illustrates a dual benefit of long-acting octreotide in the management of both occult bleeding and refractory ascites in a patient with HHT.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	BMJ Publishing Group
ISSN:	2041-4137
Date of Acceptance:	22 June 2011
Last Modified:	11 Aug 2026 09:15
URI:	https://orca.cardiff.ac.uk/id/eprint/188860

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