Continuous flow electrochemical oxidation of activated methylarenes using O2

Alqahtani, Noura, Iwai, Suguru, Boruah, Tribani, Melen, Rebecca L. ORCID: https://orcid.org/0000-0003-3142-2831 and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2026. Continuous flow electrochemical oxidation of activated methylarenes using O2. Organic & Biomolecular Chemistry 24 (33) , pp. 6754-6758. 10.1039/d6ob01129b

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Abstract

A continuous-flow electrochemical method for benzylic C–H oxidation using molecular oxygen has been developed, enabling the selective and direct conversion of toluene derivatives into aldehydes. Enhanced gas–liquid mass transfer suppresses overoxidation. Mechanistic studies implicate that reactivity is governed by oxidation potentials, offering a sustainable, catalyst-free approach to aerobic benzylic oxidation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Physical, Chemical & Environmental Sciences
Publisher:	Royal Society of Chemistry
ISSN:	1477-0520
Date of First Compliant Deposit:	17 August 2026
Date of Acceptance:	4 August 2026
Last Modified:	02 Sep 2026 14:10
URI:	https://orca.cardiff.ac.uk/id/eprint/189022

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