Adsorption and chemical transformations of lidocaine on fumed silica surface

Kulyk, T. V. ORCID: https://orcid.org/0000-0002-1740-0348, Dudik, O. O., Palyanytsya, B. B. and Barvinchenko, V. M. 2010. Adsorption and chemical transformations of lidocaine on fumed silica surface. Chemistry, Physics and Technology of Surface 1 (2) , pp. 187-193.

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Abstract

It has been found that the highest adsorption of lidocaine on silica surface is observed at рН~8.1 similar to рКа of lidocaine (рК=7.9), that is in a region of рН optimal for realization of maximum biological effect. The interaction of lidocaine with fumed silica surface has been studied by the temperature-programmed desorption mass spectrometry. Maxima for ions with m/z of 171, 147, 131, 130, 121, 116 on the thermal desorption curves have been observed at the temperature of 220-230°C for the lidocaine sample prepared by the equilibrium adsorption procedure from alkaline medium. That is, under these conditions desorption of lidocaine in molecular form takes place as a result of decomposition of adsorption complex between quaternary ammonium salt of lidocaine and silanol group. The kinetic parameters of decomposition (activation energy, order of reaction, pre-exponential factor) of this adsorption complex on silica surface have been calculated.

Item Type:	Article
Status:	Published
Schools:	Schools > Chemistry Schools > Physical, Chemical & Environmental Sciences
Publisher:	National Academy of Sciences of Ukraine
ISSN:	2079-1704
Last Modified:	11 Nov 2026 15:12
URI:	https://orca.cardiff.ac.uk/id/eprint/190857

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