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Hepatocyte growth factor is a potential lymphangiogenic factor: clinical implications

Jiang, Wen Guo ORCID: and Sanders, Andrew James ORCID: 2011. Hepatocyte growth factor is a potential lymphangiogenic factor: clinical implications. Current Signal Transduction Therapy 6 (2) , pp. 168-172. 10.2174/157436211795659900

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Hepatocyte growth factor (HGF) is a known angiogenic factor that has profound effects on vascular endothelial cells. In recent years, it has been reported that the factor also acts as a lymphagiogenic factor that induces lymphangenesis from lymphatic endothelial cells. The current article debates some of the recent evidence showing such an effect and also discusses the clinical studies that link to lymphatic related conditions, together with clinical implications.

Item Type: Article
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Hepatocyte growth factor; lymphangiogenesis; endothelial cells; VEGF; melanoma; cMET; lymph node metastases; prostate cancer; lymphatic invasion; metastasis; squamous cell carcinoma; lymphatic microvessel density; LYVE-1; Prox-1; VEGF-R3; squamous cell carcinoma; breast cancer; HGF antagonist; in vivo tumour models; D2-40 antibody; MW 40K; ERK; akt; PECAM
Publisher: Bentam Science Publishers
ISSN: 1574-3624
Last Modified: 19 Oct 2022 09:06

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