Dowman, Joanna K., Gunson, Bridget K., Bramhall, Simon, Badminton, Michael Norman and Newsome, Philip N. 2011. Liver transplantation from donors with acute intermittent porphyria [Letter]. Annals of International Medicine 154 (8) , pp. 571-572. |
Official URL: http://www.annals.org/content/154/8/571
Abstract
Background: Acute intermittent porphyria (AIP) results from partial deficiency of the enzyme porphobilinogen deaminase (1). The clinical disease includes life-threatening neurovisceral attacks from neuronal damage. The cause of these attacks has not been established but involves the heme precursor δ-aminolevulinic acid (ALA) (2). The liver is the major source of excess ALA production, and transplanting a normal liver into a patient with AIP effectively resolves this disease (3). Because clinical expression of AIP is more common in premenopausal women, we hypothesized that a liver removed from a premenopausal woman who is receiving a normal liver allograft could safely be …
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > RD Surgery |
Publisher: | American College of Physicians |
ISSN: | 1539-3704 |
Last Modified: | 04 Jun 2017 03:28 |
URI: | https://orca.cardiff.ac.uk/id/eprint/21758 |
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