Gene expression profiling following instillation of diesel exhaust particles in the lung: A first study [Abstract]

Reynolds, Laura, Berube, Kelly ORCID: https://orcid.org/0000-0002-7471-7229, Jones, Timothy Peter ORCID: https://orcid.org/0000-0002-4466-1260 and Richards, Roy J. 2000. Gene expression profiling following instillation of diesel exhaust particles in the lung: A first study [Abstract]. Microscopy and Microanalysis -New York- 6 (S2) , pp. 910-911. 10.2277/ 0521824052

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Abstract

Epidemiological studies conducted first in the USA and later in the UK, suggest that a relationship exists between increased cardio-respiratory hospital admissions, morbidity and mortality rates and increases in PM10 concentrations. In urban environments, ultrafine diesel exhaust particles (DEP), accounts for 20-80 % by mass of the airborne PM10 arising from vehicular activities. In previous work, we used well characterised DEP as a surrogate for PM10 and examined its bioreactivity in vivo by assessing lung permeability, inflammation and epithelial cell markers in lavage fluid. Delivery of a single instillate of l mg DEP into the rat lung was not found to cause progressive damage but did produce a transient change in lung permeability. In the experiment described here, we instilled two different doses (control [NaCl], 0.25 and 1.25 mg) of DEP into the rat lung and assessed the responses using the methods described above with the addition of a new technique known as gene expression profiling.

Item Type:	Short Communication
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences Schools > Earth and Environmental Sciences
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine
Additional Information:	Volume 6, Issue S2, 1 August 2000 Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania.
Publisher:	Cambridge University Press
ISBN:	9780521824057
ISSN:	1431-9276
Last Modified:	02 Sep 2026 13:16
URI:	https://orca.cardiff.ac.uk/id/eprint/21867

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