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Education, occupation and retirement age effects on the age of onset of Alzheimer's disease

Lupton, Michelle K, Stahl, Daniel, Archer, Nicola, Foy, Catherine, Poppe, Michaela, Lovestone, Simon, Hollingworth, Paul, Williams, Julie ORCID:, Owen, Michael John ORCID:, Dowzell, Kimberley Frances, Abraham, Richard Alun, Sims, Rebecca ORCID:, Brayne, Carol, Rubinsztein, David, Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn and Powell, John F 2010. Education, occupation and retirement age effects on the age of onset of Alzheimer's disease. International Journal of Geriatric Psychiatry 25 (1) , pp. 30-36. 10.1002/gps.2294

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Objective To determine the effects of early life education, mid life employment and later life retirement age on the age of onset (AOO) of Alzheimer's disease (AD). Methods Multiple regression analyses were carried out using data for 1320 probable AD cases, of which 382 were males with employment and retirement age data, using informant based information on education and employment. Results No relation was found between years of education, best qualification obtained, or employment variables in males and the AOO of AD. A significant effect of later retirement age in delaying the AOO of AD was seen in males. Conclusions In this study no effect of education or employment was seen, although this may be due to limited variance in the study population. The significant effect of retirement age may have several explanations, the most interesting of which would be the suggestion that active employment later in life allows an individual to prolong their cognitive assets above the threshold for dementia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Alzheimer's ; Cognitive research ; Occupation ; Retirement age ; Age of onset
Publisher: Wiley Blackwell
ISSN: 0885-6230
Last Modified: 05 Nov 2022 15:17

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