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Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia

Edden, Richard Anthony Edward, Harris, Ashley D., Murphy, Kevin ORCID:, Evans, Christopher John ORCID:, Saxena, Neeraj ORCID:, Hall, Judith Elizabeth ORCID:, Bailey, Damian M. and Wise, Richard Geoffrey ORCID: 2010. Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia. Journal of Magnetic Resonance Imaging 32 (2) , pp. 320-325. 10.1002/jmri.22233

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Purpose: To demonstrate the application of Mescher-Garwood (MEGA) point-resolved spectroscopy sequence (PRESS) editing to the detection of lactate in the brain at 3T and to investigate changes in lactate concentration associated with inspiratory gas challenges. Materials and Methods: Edited lactate measurements were made in six healthy volunteers while the subjects breathed normoxic (21% O2), hypoxic (12% O2), and hyperoxic (40% O2) gas mixtures. Lactate concentration was quantified relative to the unsuppressed water signal from the same volume. Results: Lactate concentration was elevated in all subjects during hypoxia in a highly significant fashion (mean increase = 39%; P = 0.0003). There was no significant change seen in hyperoxia. Conclusion: MEGA-PRESS editing at 3T is sufficiently sensitive to detect lactate in the healthy brain with good signal-to-noise ratio (SNR), and can be used to investigate changes in cerebral metabolism arising during inspiratory gas challenges.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff University Brain Research Imaging Centre (CUBRIC)
Neuroscience and Mental Health Research Institute (NMHRI)
Physics and Astronomy
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: MRS ; Lactate ; Hypoxia ; Hyperoxia ; MEGA-PRESS
Publisher: John Wiley & Sons
ISSN: 1053-1807
Last Modified: 23 May 2024 01:06

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