Assessment of the construct validity of the eq-5d in patients with acute cough/lower respiratory tract infections

Oppong, Raymond, Kaambwa, Billingsley, Nuttall, Jacqueline, Hood, Kerenza ORCID: https://orcid.org/0000-0002-5268-8631, Smith, Richard D. and Coast, Joanna 2011. Assessment of the construct validity of the eq-5d in patients with acute cough/lower respiratory tract infections. Applied Research in Quality of Life 6 (4) , pp. 411-423. 10.1007/s11482-011-9137-7

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Abstract

Although EQ-5D has been used in the context of acute cough/lower respiratory tract infections (acute cough/LRTI), it has not been formally validated in this disease area. The primary aim of this study is to assess the construct validity of EQ-5D as a measure for economic evaluation in the context of acute cough/lower respiratory tract infections. Data were collected alongside an observational study of the management of patients with acute cough/LRTI in thirteen European countries. However, the analysis was limited to 349 patients from the UK. Hypotheses were specified a priori and tested in order to establish the construct validity of EQ-5D. Statistical methods used to test the a priori hypotheses included Wilcoxon signed rank sum test, Kruskal-Wallis test, Chi-square test and regression analysis. Most of the relationships that were tested were in line with the a priori hypotheses. The main results indicate that there was a negative relationship between symptom severity scores and EQ-5D, smoking was associated with worse EQ-5D scores and EQ-5D was able to discriminate between patients with headache, interference with normal activities and disturbed sleep. This study also showed that the EQ-5D is moderately responsive in patients with acute cough/LRTI, and is a suitable measure for use in economic evaluation studies of acute cough/LRTI

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	EQ-5D; Validity; Cough; Lower respiratory tract infections
Publisher:	Springer
ISSN:	1871-2584
Last Modified:	19 Oct 2022 10:12
URI:	https://orca.cardiff.ac.uk/id/eprint/23612

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