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Excessive appetitive arousal in Prader–Willi syndrome

Hinton, Elanor Clare, Isles, Anthony Roger, Williams, Nigel Melville and Parkinson, John A. 2010. Excessive appetitive arousal in Prader–Willi syndrome. Appetite 54 (1) , pp. 225-228. 10.1016/j.appet.2009.12.002

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This study focused on genetic and behavioural aspects of one important component of the motivation to eat - how appetitive arousal is elicited through the presentation of food-associated stimuli. Individuals with Prader-Willi syndrome, a genetic disorder associated with hyperphagia, and control participants completed a computerised response task in the presence of motivational stimuli. In controls, appetitive arousal was specific to particular stimuli. In contrast, individuals with PWS showed a non-specific pattern of arousal. Over-activation of the anticipatory motivation system may be one consequence of the genetic disorder in PWS.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QP Physiology
R Medicine > R Medicine (General)
Uncontrolled Keywords: Food; Motivational arousal; Prader–Willi syndrome; Genetics; Learning; Craving
Publisher: Elsevier
ISSN: 0195-6663
Last Modified: 05 Jun 2022 07:26

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