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Behavioural and cognitive profiles of mouse models for Prader-Willi syndrome

Relkovic, Dinko and Isles, Anthony Roger ORCID: 2013. Behavioural and cognitive profiles of mouse models for Prader-Willi syndrome. Brain Research Bulletin 92 , pp. 41-48. 10.1016/j.brainresbull.2011.09.009

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Prader–Willi syndrome (PWS) is a neurodevelopmental disorder with aspects of psychiatric illness caused by genetic mutations at chromosome 15q11-q13. In addition to causing PWS, this interval is also thought to be of importance more generally in the development of autism and psychotic illness. The PWS genetic interval is conserved in mammals, and consequently mice carrying genetic manipulations affecting one or all of the genes in the region of conserved synteny have been generated and used in neurobehavioural studies. Here we give an overview of these models and describe the behavioural and neurobiological analyses that have been performed, many of which have provide new insights into the molecular and neural processes influenced by genes within the PWS interval.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Hyperphagia; Psychosis; Cognition; Serotonin; Imprinted genes; snoRNA
Publisher: Elsevier
ISSN: 0361-9230
Last Modified: 19 Oct 2022 10:21

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