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Structural basis of pattern recognition by innate immune molecules

McGreal, Eamon Patrick 2009. Structural basis of pattern recognition by innate immune molecules. Kishore, Uday, ed. Target Pattern Recognition in Innate Immunity, Advances in Experimental Medicine and Biology, vol. 653. New York: Springer, pp. 139-161.

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The importance of the innate immune system as a first line defence against pathogenic challenge has long been recognised. Over the last decade the identity of many of the key molecules mediating innate host defence have been clarified and a model of self/nonself discrimination by families of pattern recognition receptors (PRRs) has emerged. Although a large amount of information is now available concerning the action of these innate immune molecules at the level of the cell and organism, little is known about the molecular interface between pathogens and innate immune recognition molecules. In this chapter the molecular basis for innate immune discrimination of a wide variety of pathogen derived molecules is discussed in the context of the emerging literature.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Animals ; Humans ; Lectins ; Lectins, C-Type ;Toll-like Receptors ; Immunity ; Innate ; C-reactive protein ; Apoptosis regulatory
Publisher: Springer
ISBN: 9781441909008
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Last Modified: 04 Jun 2017 03:40

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