Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Does Ureaplasma spp. cause chronic lung disease of prematurity: ask the audience?

Maxwell, Nicola C., Nuttall, Diane ORCID: and Kotecha, Sailesh ORCID: 2009. Does Ureaplasma spp. cause chronic lung disease of prematurity: ask the audience? Early Human Development 85 (5) , pp. 291-296. 10.1016/j.earlhumdev.2008.12.002

Full text not available from this repository.


Ureaplasma has long been implicated in the pathogenesis of both preterm labour and neonatal morbidity, particularly chronic lung disease of prematurity (CLD), but despite numerous studies, reviews and meta-analyses, its exact role remains unclear. Many papers call for a definitive randomised control trial to determine if eradication of pulmonary Ureaplasma decreases the rates of CLD but few address in detail the obstacles to an adequately powered clinical trial. We review the evidence for Ureaplasma as a causative agent in CLD, asking why a randomised control trial has not been performed. We surveyed the opinions of senior neonatologists in the UK on whether they felt that there was sufficient evidence for Ureaplasma either causing or not causing CLD and whether a definitive trial was needed, as well as their views on the design of such a trial. Additionally, we ascertained current practice with respect to Ureaplasma detection in preterm neonates in the UK. There is clear support for an adequately powered randomised controlled clinical trial by senior neonatologists in the UK. There are no reasons why a definitive trial cannot be conducted especially as the appropriate samples, and methods to culture or identify the organism by PCR are already available.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Uncontrolled Keywords: ureaplasma, respiratory distress syndrome, chronic lung disease of prematurity, macrolides, randomised clinical trial
Publisher: Elsevier
ISSN: 0378-3782
Last Modified: 06 Dec 2022 09:19

Citation Data

Cited 12 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item