Lancaster, Thomas M., Baird, Alison, Wolf, Claudia, Jackson, Margaret C., Johnston, Stephen J., Donev, Rossen, Thome, Johannes and Linden, David Edmund Johannes ![]() |
Official URL: http://dx.doi.org/10.1016/j.euroneuro.2011.02.001
Abstract
Recent GWAS identified a risk variant for Alzheimer's disease (AD) at a locus (rs11136000) of the clusterin gene (CLU). Here we use functional magnetic resonance imaging (fMRI) during working memory to probe the effect of the risk variant on brain activation in healthy individuals. Participants with the CLU risk genotype had higher activity than participants with the protective allele in frontal and posterior cingulate cortex and the hippocampus, particularly during high memory demand. These results inform pathophysiological models of the preclinical progression of AD.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Psychology Neuroscience and Mental Health Research Institute (NMHRI) |
Subjects: | Q Science > QH Natural history > QH426 Genetics R Medicine > R Medicine (General) |
Uncontrolled Keywords: | Dementia; Genetic imaging; Working memory; Clusterin; Hippocampus; Prefrontal cortex |
Publisher: | Elsevier |
ISSN: | 0924-977X |
Last Modified: | 19 Oct 2022 10:34 |
URI: | https://orca.cardiff.ac.uk/id/eprint/24810 |
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