Human papillomavirus infection: an Anonymous Prevalence Study in South Wales, UK

Hibbits, Samantha Jayne, Hart, Keith William, Rieck, Gudrum Christine, Powell, Ned George, Hauke, A. and Fiander, Alison Nina 2006. Human papillomavirus infection: an Anonymous Prevalence Study in South Wales, UK. British Journal of Cancer 95 (2) , pp. 226-32. 10.1038/sj.bjc.6603245

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Abstract

The objective of this study was to describe human papillomavirus (HPV) prevalence in South Wales in relation to age, cytology and social deprivation. This was an unlinked, prospective, anonymous, population-based study. DNA was purified from 1911 liquid-based cytology samples (mean age 37.7 years, cytology 93.2% negative, social deprivation average score 17.9) using quality assured techniques and the presence of virus determined by PCR-Enzyme Immuno Assay (PCR-EIA). 209 (10.9%) samples contained high-risk (HR) HPV infection of which 36.4% had multiple HR-HPV types. The most frequent HR types were HPV 16 (19.6%), HPV 35 (9.5%), HPV 66 (9.2%), HPV 59 (8.5%) and HPV 56 (7.6%). There was a strong association between HPV infection and cytological abnormality. Significantly more HR-HPV infections were detected in women under the age of 30 years (68.9% of all HR-HPV infections Fisher's exact test P=0.0001) compared to 30 years and above. There was no difference in HPV prevalence between different socioeconomic groups. The data presented suggest a different HPV type distribution in South Wales in comparison to that reported for other populations.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Uncontrolled Keywords:	HPV prevalence, cervical cancer, HPV vaccine
ISSN:	15321827
Last Modified:	01 Feb 2020 22:45
URI:	https://orca.cardiff.ac.uk/id/eprint/249

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