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Human papillomavirus infection: an Anonymous Prevalence Study in South Wales, UK

Hibbits, Samantha Jayne, Hart, Keith William, Rieck, Gudrum Christine, Powell, Ned George, Hauke, A. and Fiander, Alison Nina 2006. Human papillomavirus infection: an Anonymous Prevalence Study in South Wales, UK. British Journal of Cancer 95 (2) , pp. 226-32. 10.1038/sj.bjc.6603245

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The objective of this study was to describe human papillomavirus (HPV) prevalence in South Wales in relation to age, cytology and social deprivation. This was an unlinked, prospective, anonymous, population-based study. DNA was purified from 1911 liquid-based cytology samples (mean age 37.7 years, cytology 93.2% negative, social deprivation average score 17.9) using quality assured techniques and the presence of virus determined by PCR-Enzyme Immuno Assay (PCR-EIA). 209 (10.9%) samples contained high-risk (HR) HPV infection of which 36.4% had multiple HR-HPV types. The most frequent HR types were HPV 16 (19.6%), HPV 35 (9.5%), HPV 66 (9.2%), HPV 59 (8.5%) and HPV 56 (7.6%). There was a strong association between HPV infection and cytological abnormality. Significantly more HR-HPV infections were detected in women under the age of 30 years (68.9% of all HR-HPV infections Fisher's exact test P=0.0001) compared to 30 years and above. There was no difference in HPV prevalence between different socioeconomic groups. The data presented suggest a different HPV type distribution in South Wales in comparison to that reported for other populations.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Uncontrolled Keywords: HPV prevalence, cervical cancer, HPV vaccine
ISSN: 15321827
Last Modified: 01 Feb 2020 22:45

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