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The use of fibrinogen concentrate to correct hypofibrinogenaemia rapidly during obstetric haemorrhage

Bell, Sarah F., Rayment, Rachel, Collins, Peter William ORCID: and Collis, R. E. 2010. The use of fibrinogen concentrate to correct hypofibrinogenaemia rapidly during obstetric haemorrhage. International Journal of Obstetric Anesthesia 19 (2) , pp. 218-223. 10.1016/j.ijoa.2009.08.004

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Haemorrhage is a common complication of childbirth with 0.65% of deliveries associated with significant (>1500 mL) peripartum blood loss. Hypofibrinogenaemia secondary to dilutional and consumptive coagulopathies can be challenging to correct quickly with conventional blood and plasma therapy. Fibrinogen concentrate offers rapid restoration of fibrinogen levels with a small volume infusion and minimal preparation time. It is effective in treating patients with congenital hypofibrinogenaemia, but there are few reports of its use in association with continuing obstetric haemorrhage. Six cases of obstetric haemorrhage, associated with hypofibrinogenaemia, treated with fibrinogen concentrate in conjunction with platelets, fresh frozen plasma, packed red blood cells, uterotonics and obstetric intervention are described. In all cases, laboratory assessed coagulation was rapidly normalised and severe haemorrhage improved. These cases suggest that fibrinogen concentrate may be an effective addition to conventional treatments for obstetric haemorrhage associated with hypofibrinogenaemia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RG Gynecology and obstetrics
Uncontrolled Keywords: fibrinogen concentrate, obstetric haemorrhage, hypofibrinogenaemia
Publisher: Elsevier
ISSN: 0959-289X
Last Modified: 19 Oct 2022 10:44

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