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Bispectral index asymmetry and COMFORT score in paediatric intensive care patients

Froom, Stephen R., Malan, Catherina A., Mecklenburgh, John Simon, Price, Mark A., Chawathe, Monica, Hall, Judith Elizabeth ORCID: and Goodwin, Naomi 2008. Bispectral index asymmetry and COMFORT score in paediatric intensive care patients. BJA: British Journal of Anaesthesia 100 (5) , pp. 690-696. 10.1093/bja/aen035

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Background The Bispectral Index (BIS) monitor has been suggested as a potential tool to measure depth of sedation in paediatric intensive care unit (PICU) patients. The primary aim of our observational study was to assess the difference in BIS values between the left and right sides of the brain. Secondary aims were to compare BIS and COMFORT score and to assess change in BIS with tracheal suctioning. Methods Nineteen ventilated and sedated PICU patients had paediatric BIS sensors applied to either side of their forehead. Each patient underwent physiotherapy involving tracheal suctioning. Their BIS data and corresponding COMFORT score, assessment as by their respective nurses, were recorded before, during, and after physiotherapy. Results Seven patients underwent more than one physiotherapy session; therefore, 28 sets of data were collected. The mean BIS difference values (and 95% CI) between left BIS and right BIS for pre-, during, and post-physiotherapy periods were 9.2 (5.9–12.5), 15.8 (11.9–19.7), and 7.5 (5.2–9.7), respectively. Correlation between mean BIS, left brain BIS, and right brain BIS to COMFORT score was highly significant (P<0.001 for all three) during the pre- and post-physiotherapy period, but less so during the stimulated physiotherapy period (P=0.044, P=0.014, and P=0.253, respectively). Conclusions A discrepancy between left and right brain BIS exists, especially when the patient is stimulated. COMFORT score and BIS correlate well between light and moderate sedation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RJ Pediatrics
Uncontrolled Keywords: monitoring; bispectral index; monitoring; intensive care; sedation
Publisher: Oxford University Press
ISSN: 0007-0912
Last Modified: 06 Dec 2022 09:45

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