Impact of MRI markers in subcortical vascular dementia: A multi-modal analysis in CADASIL

Viswanathan, Anand, Godin, Ophelia, Jouvent, Eric, O'Sullivan, Michael, Gschwendtner, Andreas, Peters, Nils, Duering, Marco, Guichard, Jean-Pierre, Holtmannspötter, Markus, Dufouil, Carole, Pachai, Chahin, Bousser, Marie-Germaine, Dichgans, Martin and Chabriat, Hugues 2010. Impact of MRI markers in subcortical vascular dementia: A multi-modal analysis in CADASIL. Neurobiology of Aging 31 (9) , pp. 1629-1636. 10.1016/j.neurobiolaging.2008.09.001

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Abstract

CADASIL is an arteriopathy caused by mutations of the Notch3 gene. White matter hyperintensities (WMH), lacunar lesions (LL), cerebral microhemorrhages (CM), brain atrophy and tissue microstructural changes are detected on MRI. Using an integrated multi-modal approach, we examined the relative impact of lesion burden and location of these MRImarkers on cognitive impairment and disability. Multi-modal imaging was performed on 147 patients from a two-center cohort study. Volume of LL, WMH and number of CM was determined. Whole brain mean apparent diffusion coefficient (mean-ADC) and brain parenchymal fraction (BPF) were measured. In multivariate models accounting for lesion burden and location, volume of LL, mean-ADC, and BPF each had an independent influence on global cognitive function and disability. BPF explained the largest portion of the variation in cognitive and disability scores (35–38%). Brain atrophy has the strongest independent influence on clinical impairment in CADASIL when all MRImarkers in the disease are considered together. The results suggest that the clinical impact of cerebral tissue loss plays a principal role in this genetic model of subcortical ischemic vascular dementia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	CADASIL; Cerebral microhemorrhage; Lacunar infarction; Atrophy; White matter damage; Cognitive impairment; Disability
Publisher:	Elsevier
ISSN:	0197-4580
Last Modified:	04 Jun 2017 03:44
URI:	https://orca.cardiff.ac.uk/id/eprint/25708

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