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Chapter 5.1 Memory and perceptual impairments in amnesia and dementia

Graham, Kim Samantha ORCID:, Lee, Andy C.H. and Barense, Morgan D. 2008. Chapter 5.1 Memory and perceptual impairments in amnesia and dementia. Dere, E., Easton, A., Nadel, L. and Huston, J. P., eds. Handbook of Episodic Memory, Handbook of Behavioral Neuroscience, vol. 18. Amsterdam: Elsevier, 485-501, 631. (10.1016/S1569-7339(08)00226-9)

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Recent findings from animal and human studies of memory have challenged existing accounts of the role of the medial temporal lobe (MTL) in human long-term declarative memory. These studies indicate that the MTL is not exclusively specialized for declarative long-term memory, with evidence of impairments in short-term memory and perceptual discrimination in patients with progressive and nonprogressive MTL damage. These deficits have been elicited by the increased use of paradigms developed from the animal literature which have highlighted two key factors that seem to differentially influence performance after MTL lesions: (a) whether participants are asked to perceive and remember scenes vs. objects/faces; and (b) the use of simple or complex feature ambiguous stimuli. Functional neuroimaging in healthy participants using similar paradigms has provided convergent evidence for these neuropsychological studies, revealing differential activation of two distinct networks involving different MTL regions during face and scene processing. These results are discussed with respect to existing models of the role of human MTL regions in long-term memory.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Psychology
Systems Immunity Research Institute (SIURI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: amnesia; dementia; long-term memory; working memory; perception; hippocampus; perirhinal cortex
Publisher: Elsevier
ISBN: 9780444531742
ISSN: 15697339
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Last Modified: 20 Oct 2022 07:44

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