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Polarity at illness onset in bipolar I disorder and clinical course of illness

Forty, Elizabeth, Jones, Lisa, Jones, Ian Richard, Smith, Daniel J., Caesar, Sian, Fraser, Christine, Gordon-Smith, Katherine, Hyde, Sally and Craddock, Nicholas John 2009. Polarity at illness onset in bipolar I disorder and clinical course of illness. Bipolar Disorders 11 (1) , pp. 82-88. 10.1111/j.1399-5618.2008.00654.x

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Objectives: Studies have suggested that episode polarity at illness onset in bipolar disorder may be predictive of some aspects of lifetime clinical characteristics. We here examine this possibility in a large, well-characterized sample of patients with bipolar I disorder. Methods: We assessed polarity at onset in patients with bipolar I disorder (N = 553) recruited as part of our ongoing studies of affective disorders. Lifetime clinical characteristics of illness were compared in patients who had a depressive episode at first illness onset (n = 343) and patients who had a manic episode at first illness onset (n = 210). Results: Several lifetime clinical features differed between patients according to the polarity of their onset episode of illness. A logistic regression analysis showed that the lifetime clinical features significantly associated with a depressive episode at illness onset in our sample were: an earlier age at illness onset; a predominantly depressive polarity during the lifetime; more frequent and more severe depressive episodes; and less prominent lifetime psychotic features. Conclusions: Knowledge of pole of onset may help the clinician in providing prognostic information and management advice to an individual with bipolar disorder.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: affective disorder, bipolar disorder, depression, mania, onset polarity
Publisher: Wiley
ISSN: 1398-5647
Last Modified: 15 Jul 2021 01:22

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