Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adults

Bloemen, Oswald J. N., Deeley, Quinton, Sundram, Fred, Daly, Eileen M., Barker, Gareth J., Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049, van Amelsvoort, Therese A. M. J., Schmitz, Nicole, Robertson, Dene, Murphy, Kieran C. and Murphy, Declan G. M. 2010. White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adults. Autism Research 3 (5) , pp. 203-213. 10.1002/aur.146

Full text not available from this repository.

Abstract

Background: Autistic Spectrum Disorder (ASD), including Asperger syndrome and autism, is a highly genetic neurodevelopmental disorder. There is a consensus that ASD has a biological basis, and it has been proposed that it is a “connectivity” disorder. Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) allows measurement of the microstructural integrity of white matter (a proxy measure of “connectivity”). However, nobody has investigated the microstructural integrity of whole brain white matter in people with Asperger syndrome. Methods: We measured the fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) of white matter, using DT-MRI, in 13 adults with Asperger syndrome and 13 controls. The groups did not differ significantly in overall intelligence and age. FA, MD and RD were assessed using whole brain voxel-based techniques. Results: Adults with Asperger syndrome had a significantly lower FA than controls in 13 clusters. These were largely bilateral and included white matter in the internal capsule, frontal, temporal, parietal and occipital lobes, cingulum and corpus callosum. Conclusions: Adults with Asperger syndrome have widespread significant differences from controls in white matter microstructural integrity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff University Brain Research Imaging Centre (CUBRIC)
Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: autism; Asperger syndrome; white matter; DTI; connectivity
Publisher: Wiley
ISSN: 1939-3792
Last Modified: 20 Oct 2022 07:52
URI: https://orca.cardiff.ac.uk/id/eprint/26724

Citation Data

Cited 66 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item