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Commentary: Testosterone and the metabolic syndrome: cause or consequence?

Rees, Dafydd Aled ORCID: and Dayan, Colin Mark ORCID: 2010. Commentary: Testosterone and the metabolic syndrome: cause or consequence? International Journal of Epidemiology 40 (1) , pp. 207-209. 10.1093/ije/dyq254

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The Metabolic Syndrome (MetS), which affects approximately 15–25% of the adult population, comprises a cluster of cardiovascular risk factors that include central obesity, hypertension, hypertriglyceridaemia, glucose intolerance/insulin resistance and reduced high-density lipoprotein cholesterol levels. The presence of the syndrome conveys a significantly increased risk of type 2 diabetes (T2DM) and cardiovascular disease, hence identifying interventions that reduce the prevalence of the syndrome must be viewed as a major public health priority. In this issue of the journal, Brand et al.1 report their findings from a systematic review and meta-analysis of observational studies, which examined the association between testosterone (both total and free), its major carrier protein sex hormone binding globulin (SHBG) and the MetS. Their findings confirm a gender-dependent association between testosterone and the MetS, in which total and free testosterone levels are lower in men with the MetS but higher in women with the MetS, compared with those without. How can these relationships be explained and what is the significance of their observations for clinical practice? Clinicians treating men with the MetS and/or T2DM will recognize low testosterone readings in their patients as a common finding. A previous meta-analysis of 2900 men, 850 of whom had T2DM, showed that total testosterone was lowered by a mean of −2.66 nmol/l in …

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Publisher: Oxford University Press
ISSN: 0300 5771
Last Modified: 06 Nov 2022 13:21

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