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Birth outcomes following treatment for precancerous changes to the cervix: a population-based record linkage study

Reilly, R., Paranjothy, Shantini ORCID:, Beer, H., Brooks, C. J., Fielder, Hilary Margaret and Lyons, R. A. 2012. Birth outcomes following treatment for precancerous changes to the cervix: a population-based record linkage study. BJOG: An International Journal of Obstetrics & Gynaecology 119 (2) , pp. 236-244. 10.1111/j.1471-0528.2011.03052.x

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Objective To examine whether treatments for precancerous changes to the cervix are associated with adverse birth outcomes in subsequent pregnancies. Design Population-based retrospective cohort study using electronic linkage of data from the Welsh cervical screening programme and a national routine child health database. Setting Wales. Population A total of 174 325 women aged 20–39 years who received cervical screening between April 2001 and March 2004. Methods Logistic regression was used to compare the odds of each birth outcome between women who had negative cervical smearsand women who received either colposcopy ± punch biopsy onlyor colposcopy and excisional or ablative treatments, adjusted for confounding factors (e.g. age, social deprivation and smoking). Main outcome measures Preterm birth (before 37, 32 and 28 weeks of gestation), and low birthweight (<2500 g). Results Compared with women who had negative cervical smears, the odds ratio for preterm birth (<37 weeks) was significantly increased in women who had colposcopy only (adjusted odds ratio 1.54, 95% CI 1.32–1.80) and single excisional treatment (adjusted odds ratio 1.77, 95% CI 1.47–2.13). Similar results were observed for preterm birth at <32 weeks of gestation. There was no increased risk of preterm birth or low birthweight for women who had treatment compared with women who had colposcopy only. Conclusion Women who were referred for colposcopy had an increased risk of preterm births regardless of whether or not they received treatment to the cervix. This increased risk could be the result of common risk factors for abnormal smears and preterm birth.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RG Gynecology and obstetrics
Uncontrolled Keywords: Ablative ; cervical treatment ; excisional ; low birthweight ; preterm birth
Publisher: Blackwell Publishing
ISSN: 1470-0328
Last Modified: 20 Oct 2022 08:08

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