A framework for interpreting genome-wide association studies of psychiatric disorders

Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 2008. A framework for interpreting genome-wide association studies of psychiatric disorders. Molecular Psychiatry 14 (1) , pp. 10-17. 10.1038/mp.2008.126

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Abstract

Genome-wide association studies (GWAS) have yielded a plethora of new findings in the past 3 years. By early 2009, GWAS on 47 samples of subjects with attention-deficit hyperactivity disorder, autism, bipolar disorder, major depressive disorder and schizophrenia will be completed. Taken together, these GWAS constitute the largest biological experiment ever conducted in psychiatry (59 000 independent cases and controls, 7700 family trios and >40 billion genotypes). We know that GWAS can work, and the question now is whether it will work for psychiatric disorders. In this review, we describe these studies, the Psychiatric GWAS Consortium for meta-analyses of these data, and provide a logical framework for interpretation of some of the conceivable outcomes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	genome-wide association, attention-deficit hyperactivity disorder, autism, bipolar disorder, major depressive disorder, schizophrenia
Publisher:	Nature Publishing Group
ISSN:	1359-4184
Last Modified:	20 Oct 2022 08:14
URI:	https://orca.cardiff.ac.uk/id/eprint/27696

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