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Proteomics and peritoneal dialysis: early days but clear potential

Brewis, Ian Andrew and Topley, Nicholas 2010. Proteomics and peritoneal dialysis: early days but clear potential. Nephrology Dialysis Transplantation 25 (6) , pp. 1749-1753. 10.1093/ndt/gfq145

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The application of proteomics (the study of protein products expressed by the genome) has become one of the leading post-genomic technologies given the increased understanding of the central role of proteins and protein–protein interactions in all aspects of cellular function [2]. Systematic global identification and quantification of proteins can, not only inform improved biomedical understanding of a particular system in healthy or diseased individuals, but also be used for protein biomarker discovery. The most popular of the many proteomic strategies available are summarized in Figure 1 and, whilst two-dimensional electrophoresis (2DE) gel-based approach remains popular, liquid chromatography–tandem mass spectrometry (LC-MS/MS) and gel electrophoresis then liquid chromatography mass spectrometry (geLC-MS) approaches are now preferred as state-of-the-art.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Uncontrolled Keywords: Biomarker ; Dialysis ; Peritoneal fluid ; Proteomics
Publisher: Oxford University Press
ISSN: 0931-0509
Last Modified: 30 Jun 2017 02:24

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