Heinsbroek, Sigrid E. M., Taylor, Philip Russel ![]() |
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Abstract
Candida albicans is a medically important pathogen, and recognition by innate immune cells is critical for its clearance. Although a number of pattern recognition receptors have been shown to be involved in recognition and phagocytosis of this fungus, the relative role of these receptors has not been formally examined. In this paper, we have investigated the contribution of the mannose receptor, Dectin-1, and complement receptor 3; and we have demonstrated that Dectin-1 is the main non-opsonic receptor involved in fungal uptake. However, both Dectin-1 and complement receptor 3 were found to accumulate at the site of uptake, while mannose receptor accumulated on C. albicans phagosomes at later stages. These results suggest a potential role for MR in phagosome sampling; and, accordingly, MR deficiency led to a reduction in TNF-α and MCP-1 production in response to C. albicans uptake. Our data suggest that pattern recognition receptors sample the fungal phagosome in a sequential fashion.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine Systems Immunity Research Institute (SIURI) |
Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > R Medicine (General) R Medicine > RB Pathology |
Publisher: | Public Library of Science |
ISSN: | 1553-7374 |
Funders: | Wellcome Trust, Medical Research Council, EPA Cephalosporin Scholarship, Henry Goodger Scholarship |
Date of First Compliant Deposit: | 30 March 2016 |
Last Modified: | 21 May 2023 04:15 |
URI: | https://orca.cardiff.ac.uk/id/eprint/28791 |
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