Association of measures of fetal and childhood growth with non-clinical psychotic symptoms in 12-year-olds: the ALSPAC cohort

Thomas, Kate, Harrison, Glynn, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211, Lewis, Glyn, Horwood, Jeremy, Heron, J., Hollis, Chris, Wolke, Dieter, Thompson, Andrew and Gunnell, David 2009. Association of measures of fetal and childhood growth with non-clinical psychotic symptoms in 12-year-olds: the ALSPAC cohort. British Journal of Psychiatry 194 (6) , pp. 521-526. 10.1192/bjp.bp.108.051730

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Abstract

Background Previous studies have suggested that impaired fetal and childhood growth are associated with an increased risk of schizophrenia, but the association of pre-adult growth with non-clinical psychotic symptoms (psychosis-like symptoms) in children is not known. Aims To explore the associations of body size at birth and age 7.5 years with childhood psychosis-like symptoms. Method Prospective cohort of children followed up from birth to age 12: the ALSPAC cohort. Results Data on 6000 singleton infants born after 37 weeks of gestation. A one standard deviation increase in birth weight was associated with an 18% reduction in the risk of definite psychosis-like symptoms after adjusting for age and gestation (Odds ratio (OR) = 0.82, 95% CI = 0.73–0.92, P = 0.001). This association was partly confounded by maternal anthropometry, smoking during pregnancy, socioeconomic status and IQ. A similar association was seen for birth length and psychosis-like symptoms, which disappeared after controlling for birth weight. There was little evidence for an association of 7-year height or adiposity with psychosis-like symptoms. Conclusions Measures of impaired fetal, but not childhood, growth are associated with an increased risk of psychosis-like symptoms in 12-year-olds.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RG Gynecology and obstetrics R Medicine > RJ Pediatrics R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Publisher:	Royal College of Psychiatrists
ISSN:	0007-1250
Last Modified:	20 Oct 2022 08:34
URI:	https://orca.cardiff.ac.uk/id/eprint/28839

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