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Pre-conception inter-pregnancy interval and risk of schizophrenia

Gunawardana, Lihini, Smith, G. D., Zammit, Stanley, Whitley, E., Gunnell, D., Lewis, S. and Rasmussen, F. 2011. Pre-conception inter-pregnancy interval and risk of schizophrenia. British Journal of Psychiatry 199 (4) , pp. 338-339. 10.1192/bjp.bp.111.092916

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It is hypothesised that the risk of schizophrenia may be elevated in children conceived following a short inter-pregnancy interval, when maternal folate stores are still being replenished. We examined the relationship between inter-pregnancy interval and schizophrenia risk in a longitudinal, population-based cohort. Risk of schizophrenia was increased by approximately 150% in those born following a pregnancy interval of ≤6 months, but was not increased if the interval after birth of the participant, before conception of the subsequent sibling, was ≤6 months. These findings support the hypothesis that folate (or other micronutrient) deficiency during fetal development may be an important risk factor for schizophrenia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RG Gynecology and obstetrics
Publisher: Royal College of Psychiatrists
ISSN: 0007-1250
Last Modified: 04 Jun 2017 03:55

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