Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Disentangling genetic and environmental influences on children’s development: introducing a novel methodology

Harold, Gordon Thomas, Shelton, Katherine Helen ORCID:, Rice, Frances ORCID:, Boivin, Jacky ORCID:, Hay, Dale F. ORCID:, van den Bree, Marianne Bernadette ORCID: and Thapar, Anita ORCID: 2008. Disentangling genetic and environmental influences on children’s development: introducing a novel methodology. Acta Psychologica Sinica 40 (10) , pp. 1124-1134.

Full text not available from this repository.


The present study describes a novel methodology to examine the interplay between genetic and environmental influences on children’s development. Families of children aged 4 – 10 years born by one of five methods of assisted reproductive technologies, specifically homologous in vitro fertilization (IVF), sperm donation, egg donation, embryo donation, and gestational surrogacy, were contacted through fertility clinics and mailed a set of questionnaires focusing on the quality of family interaction, parenting, marital satisfaction, parent and child psychological health, economic conditions and family demographics. Analyses are described that highlight the novelty of this research design to disentangle genetic, intrauterine and early social environmental influences on children’s development. First, results are described whereby comparisons were made between children born through assisted reproductive technologies and children conceived naturally in relation to patterns of association between levels of interparental conflict, parent-to-child hostility and children’s symptoms of depression. Second, results are described where comparisons were made between patterns of association between parent depressive symptoms, family relationship quality (interparental and parent-child relations) and children’s symptoms of depression. Finally, a strategy that allows examination of relative genetic and intrauterine environmental influences on children’s health and mental health outcomes is described. Results are discussed in relation to implications for development of future intervention and prevention programmes

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RJ Pediatrics
Uncontrolled Keywords: assisted reproductive technologies, family relationships, gene × environment interaction
Publisher: Magtech
ISSN: 0439-755X
Last Modified: 06 May 2023 01:39

Actions (repository staff only)

Edit Item Edit Item