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Extrathyroidal thyroid hormone synthesis?

Ludgate, Marian Elizabeth 2011. Extrathyroidal thyroid hormone synthesis? Journal of Endocrinology 210 (1) , pp. 3-4. 10.1530/JOE-11-0159

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A paper published in the Journal of Endocrinology, has revisited the hypothesis that thyroid hormones may be generated by tissues outside the thyroid gland in higher organisms, including mammals. This commentary appraises the strengths and weaknesses of the study, the alternative explanations for the findings and possible future measures to investigate further. The concept of extrathyroidal thyroxine (T4) and triiodothyronine (T3) synthesis has been proposed previously; having assumed that Nagao et al and earlier authors are correct, the plausibility and possible mechanisms underlying the hypothesis are discussed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: thyroid; thyroxine; tri-iodothyronine; iodothyronines; iodotyrosines; deiodinase; thyroid peroxidase; thyroglobulin, sodium iodide symporter; dual oxidases; endostyle
Additional Information: Commentary on: ‘Influence of thyroidectomy on thyroxine metabolism and turnover rate in rats’, Nagao et al. (2011) Journal of Endocrinology 210 117–123. (doi:10.1530/JOE-10-0484)
Publisher: Society for Endocrinology
ISSN: 0022-0795
Related URLs:
Last Modified: 04 Jun 2017 03:58

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