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The expanding genetic overlap between multiple sclerosis and type I diabetes

Booth, David R., Heard, Robert N., Stewart, Graeme J., Goris, An, Dobosi, Rita, Dubois, Bénédicte, Lorentzen, Åslaug R., Celius, Elisabeth G., Harbo, Hanne F., Spurkland, Anne, Olsson, Tomas, Kockum, Ingrid, Link, Jenny, Hillert, Jan, Ban, Maria, Baker, Amie, Sawcer, Stephen, Compston, Alastair, Mihalova, Tania, Strange, Richard, Hawkins, Clive, Ingram, Gillian, Robertson, Neil ORCID:, De Jager, Philip L., Hafler, David A., Barcellos, Lisa F., Ivinson, Adrian J., Pericak-Vance, Margaret, Oksenberg, Jorge R., Hauser, Stephen L., McCauley, Jacob L., Sexton, David and Haines, Jonathan 2009. The expanding genetic overlap between multiple sclerosis and type I diabetes. Genes and Immunity 10 (1) , pp. 11-14. 10.1038/gene.2008.83

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Familial clustering of autoimmune disease is well recognized and raises the possibility that some susceptibility genes may predispose to autoimmunity in general. In light of this observation, it might be expected that some of the variants of established relevance in one autoimmune disease may also be relevant in other related conditions. On the basis of this hypothesis, we tested seven single nucleotide polymorphisms (SNPs) that are known to be associated with type I diabetes in a large multiple sclerosis data set consisting of 2369 trio families, 5737 cases and 10 296 unrelated controls. Two of these seven SNPs showed evidence of association with multiple sclerosis; that is rs12708716 from the CLEC16A gene (P=1.6 × 10−16) and rs763361 from the CD226 gene (P=5.4 × 10−8). These findings thereby identify two additional multiple sclerosis susceptibility genes and lend support to the notion of autoimmune susceptibility genes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology > QR180 Immunology
Publisher: Nature Publishing Group
ISSN: 1466-4879
Last Modified: 20 Oct 2022 08:56

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