Influence of body weight on the performance of glomerular filtration rate estimators in subjects with type 2 diabetes

Chudleigh, Richard A., Dunseath, Gareth John, Peter, Rajesh, Harvey, John N., Ollerton, Richard L., Luzio, Stephen Denis and Owens, David Raymond 2008. Influence of body weight on the performance of glomerular filtration rate estimators in subjects with type 2 diabetes. Diabetes Care 31 (1) , pp. 47-49. 10.2337/dc07-1335

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Abstract

The American Diabetes Association recommends estimation of glomerular filtration rate (GFR) (1) by either the Cockcroft-Gault (2) or the Modification of Diet in Renal Disease (MDRD) (3) equation in all patients with diabetes. The implication is that these equations provide similar results. Body weight is a numerator in the Cockcroft-Gault equation; however, it is absent from the MDRD equation. This may explain some of the difference in the ability of these equations to estimate GFR in patients with type 2 diabetes, over 80% of whom are obese (4), and may lead to discrepancies in reporting of chronic kidney disease stage (5). Our study was designed to identify whether body weight may explain variability in performance between the Cockcroft-Gault and MDRD equations in patients newly diagnosed with type 2 diabetes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	BSA, body surface area; eGFR, estimated glomerular filtration rate; GFR, glomerular filtration rate; MDRD, Modification of Diet in Renal Disease
Publisher:	American Diabetes Association
ISSN:	0149-5992
Last Modified:	07 Dec 2022 07:37
URI:	https://orca.cardiff.ac.uk/id/eprint/30197

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