Functional themes from psychiatric genome-wide screens

Davies, William ORCID: https://orcid.org/0000-0002-7714-2440 2011. Functional themes from psychiatric genome-wide screens. Frontiers in Genetics 2 , 89. 10.3389/fgene.2011.00089

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Abstract

Technological advances and a greater degree of inter-laboratory co-operation mean that genome-wide analyses can now be used to identify genetic variants that are robustly associated with the risk of developing psychiatric and neurological disorders. In contrast to the candidate gene approach, such screens may identify variants within genes which have a hitherto unappreciated role in disorder pathogenesis, and whose brain function is obscure. In this Perspective, I discuss how the behavioral functions of such genes may be investigated using model systems, drawing attention to the potential caveats and limitations with such approaches. The power of focused cross-species studies needs to be effectively exploited to enable useful insights into the molecular pathogenesis of common and disabling disorders, and ultimately to provide better clinical outcomes for patients.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	behavior, copy number variant, mouse, rat, single nucleotide polymorphism
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/1664-8021/ (accessed 25/02/2014). This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
Publisher:	Frontiers Media
ISSN:	1664-8021
Date of First Compliant Deposit:	30 March 2016
Last Modified:	28 Sep 2023 23:13
URI:	https://orca.cardiff.ac.uk/id/eprint/31311

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