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A calibration method for quantitative BOLD fMRI based on hyperoxia

Chiarelli, Peter A., Bulte, Daniel P., Wise, Richard Geoffrey ORCID:, Gallichan, Daniel ORCID: and Jezzard, Peter 2007. A calibration method for quantitative BOLD fMRI based on hyperoxia. Neuroimage 37 (3) , pp. 808-820. 10.1016/j.neuroimage.2007.05.033

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The estimation of changes in CMRO2 using functional MRI involves an essential calibration step using a vasoactive agent to induce an isometabolic change in CBF. This calibration procedure is performed most commonly using hypercapnia as the isometabolic stimulus. However, hypercapnia possesses a number of detrimental side effects. Here, a new method is presented using hyperoxia to perform the same calibration step. This procedure requires independent measurement of PaO2, the BOLD signal, and CBF. We demonstrate that this method yields results that are comparable to those derived using other methods. Further, the hyperoxia technique is able to provide an estimate of the calibration constant that has lower overall intersubject and intersession variability compared to the hypercapnia approach.

Item Type: Article
Status: Published
Schools: Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Elsevier
ISSN: 1053-8119
Last Modified: 07 Nov 2022 08:39

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