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Relationship between impulsive sensation seeking traits, smoking, alcohol and caffeine intake, and Parkinson's disease

Evans, A. H., Lawrence, Andrew David ORCID:, Potts, J., MacGregor, L., Katzenschläger, R., Shaw, K., Zijlmans, J. and Lees, A. J. 2005. Relationship between impulsive sensation seeking traits, smoking, alcohol and caffeine intake, and Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry 77 (3) , pp. 317-321. 10.1136/jnnp.2005.065417

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Background: An inverse relation exists between smoking and coffee intake and Parkinson’s disease (PD). The present study explored whether this is explained by low sensation seeking, a personality trait believed to characterise PD. Methods: A total of 106 non-demented patients with PD and 106 age and sex matched healthy controls completed a short version of Zuckerman’s Sensation Seeking Scale (SSS), the Geriatric Depression Scale, and the Trait Anxiety Inventory. Data were collected on past and current cigarette smoking, and participants also completed food frequency questionnaires to estimate current caffeine and alcohol intake. Results: Patients with PD had lower sensation seeking and higher depression and anxiety scores. They were also less likely to have ever smoked, and had lower caffeine and alcohol intakes. Analysis of the data using conditional logistic regression suggested that the inverse association of PD risk with sensation seeking was independent of smoking, and caffeine and alcohol intake. Moreover, low sensation seeking explained some of the apparent effect of caffeine and alcohol intake on PD. However, the effect of smoking was weakened only slightly when SSS was included in the regression model. Conclusion: This study raises the possibility that there is a neurobiological link between low sensation seeking traits—which might underlie the parkinsonian personality—and the hypothetical protective effect of cigarette smoking and caffeine consumption on PD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > R Medicine (General)
Publisher: BMJ Publishing Group
ISSN: 0022-3050
Last Modified: 20 Oct 2022 09:43

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